We performed polygenic analyses in the ABCD sample.116 Again using PRS-CS,117 we fitted a fixed effects model in the ABCD European subsample (wave 3 for phenotypes, wave 3 for genotypes), controlling for first 10 PCs, age, sex, site, as fixed effect covariates and family ID as random effects covariates. We included 12 measures that showed significant rg in the adults datasets and were available in this cohort; these included 2 binary phenotypes (pain, “any pain last month”; and suicide attempt, “description”), and 10 continuous measures (from the CBCL child behavior checklist118- “CBCL Externalizing”, “CBCL ADHD”, “CBCL Depression”, “CBCL ADHD”, “CBCL AnxDep”; “CBCL AnxDis”, “CBCL OCD”; cognitive ability via the NIH cognitive toolbox total score;119 BMI; weight; deprivation). Results were corrected for multiple testing (p<4.0E-03). Additional genotyping, QC and statistical details are described in the Supplementary Material.
