evident. Nevertheless, we decided not to adjust these analyses for BMI: our results of a shared genetic basis sustain indeed the hypothesis that atypical depression and BMI-related metabolic dysregulations may represent epiphenomenon stemming from the same pathophysiological mechanism, and adjusting for BMI may therefore represent an overadjustment. Nevertheless, the association with GPRS-BMI was unchanged when using only the increased appetite symptom to define the atypical-like subtype. Finally, no genetic overlap was found between MDD or the atypical subtype with CRP. This is in line with a recent large mendelian-randomization study showing that genetically elevated CRP is not associated with increased risk of depression(48).
