paperKB
coga / coga-kb
Help
Sign in

Chunk #6 — Statistical Methods — Factor Analysis

Source
Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.
Embedded
yes

Text

were also included as covariates. The effect of possible non-normality of the trait value on the Type I error rate of the linear regression analysis was tested by generating 10,000,000 random sets of genotypes for each of 3 minor allele frequencies 0.1, 0.25, 0.5. Regression of the trait on these genotype sets was performed, and Type I error rate estimated as the proportion of sets where the regression reached significance. No inflation of observed Type I error rate compared to nominal values was observed for any of the significance levels tested (ranging from 0.05 to 10-6). Thus, it was not considered necessary to perform a transformation on the factor scores.