These results concur with our finding of a widespread and generalized connectivity deficit in schizophrenia, which particularly affects functional integration between frontal cortex and other regions. Measuring connectivity differences across a range of tasks in the same sample will help to clarify precisely how generalized these effects are. Another important question concerns whether these generalized connectivity deficits reflect alterations in underlying anatomical connectivity (64–66). Studies combining fMRI with diffusion-based imaging are necessary to address this question.
