Chunk #0 — Introduction

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A mega-analysis of genome-wide association studies for major depressive disorder.

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Major depressive disorder (MDD) is a genetically complex trait. The lifetime prevalence of MDD is ~15%.1,2 As a recurrent course is most common,3 MDD is accompanied by considerable morbidity4–6 excess mortality5,7 and substantial costs.8 The World Health Organization projects MDD to be the second leading cause of disability by 2020.9