Both patients and control subjects showed increased global integration (i.e., lower normalized path length, λ) and reduced local information processing (i.e., lower local efficiency, EL) in the more difficult B cue condition, suggesting that global properties of brain network organization are responsive to changing task contexts (74). These findings are consistent with evidence that increased global integration of functional brain networks is a marker of adaptive behavior (75,76). The findings were not uniform across other measures of similar topological properties (e.g., we found no effects for EG or γ), however, and should be interpreted with respect to differences in how these measures are computed (Section S2 in Supplement 1).
