We used DEPICT to identify the most likely causal gene at a given associated locus, reconstituted gene sets enriched for BMI associations, and tissues and cell types in which genes from associated loci are highly expressed21. To accomplish this, the method relies on publicly available gene sets (including molecular pathways) and uses gene expression data from 77,840 gene expression arrays75 to predict which other genes are likely to be part of these gene sets, thus combining known annotations with predicted annotations. For details and negative control analyses please see Supplementary Methods.
