In contrast, PRS are uniformly less useful in understudied populations due to differences in genomic variation and population history13,14. No analogous solution of defining ethnicity-specific reference intervals would ameliorate health disparities implications for PRS or fundamentally aid interpretability in non-European populations. Rather, as we and others demonstrate, PRS are unique in that even with multi-ethnic population references, these scores are fundamentally less informative in populations more diverged from GWAS study cohorts.
