again suggested that F- and B-iPSCs are highly similar to each other. To quantify both abnormal methylation and somatic memory phenotypes we compared the methylation signatures of hESCs, isogenic iPSC lines, and somatic parental cells using k-means clustering (Figure S3). We found that the methylation profiles of 7%–25% of DMCs in iPSCs resembled those of the corresponding parental somatic cells (Figure 2C), and often exhibited a donor-specific signature of memory. On average, 70% of DMCs were similar to hESCs (Figure 2C), which is in line with previous reports (Bock et al., 2011).
