We acknowledge that remission is not a static construct and includes much individual variation in type and length of remission and periods of symptomatic drinking. A limitation of this study is that we did not account for this variation but instead elected to use a simple definition of at least one 12-month period of remission to increase power to detect a genetic association and increase the potential for replication in other samples that may have less detail about alcohol use and AUD. Despite the strength of examining both EA and AA samples, the COGA AA sample size was small, especially for non-abstinent remission. In addition, the sample size of the AA discovery dataset used to calculate AA PGSAUD was much smaller than EA discovery dataset, resulting in sub-optimal performance of AA PGSAUD. Therefore, the non-significant findings of AA PGSAUD could be at least partially due to small sample sizes of COGA AA and the AA discovery dataset. Another limitation is that participants in Indiana Biobank were not ascertained to study AUD and related traits. All data were obtained from EHR,
