in two distinct accessibility assays. To further validate the discovery of these putative trans-regulators we calculated aggregate TF “footprints”, a measure of the DNase or Tn5 cut density around the given motif, and found a diverse set of accessibility profiles (Supplementary Fig. 12). Interestingly, several of these motifs did not match canonical narrow (~20 bp) transcription factor footprints, but rather are associated with a large footprint (>20 bp) potentially indicative of larger regulatory complexes.
