In rats that had not been selected for alcohol preference, NK1R antagonism did not affect alcohol self-administration or two bottle choice consumption until doses were reached that also suppressed sucrose consumption, indicating actions on appetitive behavior that were not selective for alcohol (Steensland et al., 2010). However, systemic NK1R antagonist administration suppressed stress induced reinstatement of alcohol-seeking in non-selected rats, at doses that had no effect on baseline operant self-administration of alcohol or sucrose, cue-induced reinstatement of alcohol seeking, or novel environment-induced locomotion (Schank et al., 2011).
