In CHRNB1, rs7210231 is the most strongly associated in the full sample and shows modest evidence for consistent effects across populations (OR = 0.79(0.62-1.02) in AAs, OR = 0.77(0.66-0.9) in EAs). CHRNB1 is abundantly expressed in the neuromuscular junctions of muscles as well as showing a low level of mRNA expression in the brain.
