In summary, all four density (vs. dichotomous) measures presented greater diagnostic accuracy in males, females, Whites and Blacks. All four density (vs. dichotomous) measures presented robust associations with all three outcomes, especially in males and Whites. All four density (vs. dichotomous) measures were significantly associated with likelihood of AUD and age of onset of regular drinking in females and only with age of onset of regular drinking, in Blacks. These results corroborate previous findings that density measures of FH have greater predictive value. Nevertheless, the variations observed in the association of density and dichotomous FH measures with P3 amplitude, especially in females (vs. males) and Blacks (vs. Whites), indicate that utility of FH measures may differ depending on the phenotype and the social groups being studied.
