The observed number of hits in the RDC schizoaffective disorder, bipolar type set was achieved only once in any of the 2500 simulations of 279 participants randomly selected from the bipolar disorder data-set and compared with the controls. This corresponds to an empirical significance of P = 0.0004 for the null hypothesis that the RDC schizoaffective disorder, bipolar type set does not differ genetically from the bipolar disorder sample as a whole. A conservative Bonferroni correction for multiple testing of seven subsets gives an empirical significance of P = 0.0028. None of the other diagnostic sets differed from chance expectation (P>0.05).
