Chunk #74 — Potential for Translational Applications of Electrophysiological Measures of Brain Function — Electrophysiological Measures As Endophenotypes for Alcoholism
In addition to resting-state EEG endophenotypes, P3-related measures during cognitive tasks (e.g., oddball task) have been successfully used as endophenotypes to identify genes related to alcoholism. Chen and colleagues (2010) reported significant associations between the P3 amplitude to visual targets as well as to alcohol dependence diagnosis with multiple single nucleotide polymorphisms (SNPs) in the corticotrophin-releasing hormone receptor 1 (CRHR1) gene, which has been shown to have a role in the environmental stress response in ethanol self-administration animal models.
