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Chunk #15 — Methods — Regions-of-interest (ROI) analyses

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Disrupted functional connectivity with dopaminergic midbrain in cocaine abusers.
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The relevant clusters were further evaluated with region-of-interest (ROI) analyses to identify potential outliers that might influence statistical analyses, and to report average values in a volume comparable to the image smoothness (e.g. resolution elements, or “resels” [34]) rather than single-voxel peak values. The volume of the resels was estimated using the random field calculation in SPM2 as a near cubic volume with Cartesian full-width-half-maximum (FWHM) of [13.0, 12.3, 13.4] mm for group analyses of brain activation and of [11.8, 11.0, 12.4] mm for group analyses of CM. Note that (2n+1)3 voxels fit into ROI that are symmetric around a peak voxel and that 3-mm isotropic voxels were used. We did not use n = 0 ROIs because do not take full advantage of the 13-mm isotropic resels (include only one voxel). Similarly, n = 2 ROIs were not used because they include voxels that do not belong to the average functional cluster defined by the resels. Thus, n = 1 ROIs were used to maximize the number of voxels within the smoothness of the data. Thus, the average BOLD