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Chunk #16 — Methods — EEG-Source Localization Analysis

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Resting-state network disruption and APOE genotype in Alzheimer's disease: a lagged functional connectivity study.
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The current eLORETA implementation employs a three-shell spherical head model and EEG electrode coordinates derived from cross-registrations between spherical and realistic Talaraich head geometry. The head model and the electrode coordinates were registered to the Montreal Neurologic Institute average MRI brain (MNI152) [49]. The solution space was restricted to the cortical gray matter, corresponding to 6239 voxels at 5×5×5 mm spatial resolution. Validation for the eLORETA tomography rests upon the abundant published validation for the previous LORETA and sLORETA methods using fMRI [50], [51], structural MRI [52], PET [53], and intracranial EEG recordings [54].