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Chunk #18 — Results — Working Memory

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Large-scale brain network coupling predicts acute nicotine abstinence effects on craving and cognitive function.
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Finally, to further instantiate that the RAI has unique merit, we investigated the relationship between zSN,DMN and urge scores and between zSN,DMN and WM task-induced BOLD deactivation. Coupling between the SN and DMN alone did not produce the observed RAI behavioral and neural relationships (zSN,DMN and urge association, P = .38; zSN,DMN and WM-task-induced BOLD deactivation association, P = .59 [VMPFC] and P = .05 [PCC]). These results show the importance of collective between-network interactions in accounting for observed behavioral changes.