Chunk #24 — Results — Hypersensitivity to ethanol in C. elegans unc-79, unc-80, and nca-1;nca-2 double mutants suggests a conserved role of these genes in ethanol-related behaviors
Our observations in Lwt/+ mice led us to revisit the possibility that C. elegans unc-79 mutants were also hypersensitive to acute ethanol exposure. A previous study reported that unc-79 mutants were modestly resistant to ethanol-induced immobility in liquid media [6]. They also reported no alteration in sensitivity to ethanol in unc-80 mutants [6]. In contrast, we observed a pronounced hypersensitivity to ethanol in unc-79, unc-80, and nca-1;nca-2 double mutants when compared to wild-type N2 animals (Figure 10).
