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Chunk #0 — 1. INTRODUCTION

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Improved methods to identify stable, highly heritable subtypes of opioid use and related behaviors.
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Opioid dependence (OD) is a serious, prevalent disorder and the number of people using opioids in the United States has been increasing since 1990 (Anthony et al., 1994; Regier et al., 1990; Substance Abuse and Mental Health Services Administration, 2007). In 2006, 0.8% of Americans aged 12 or older met criteria for a lifetime opioid use disorder and 0.4% were treated for an opioid-related problem in the past year (Substance Abuse and Mental Health Services Administration, 2007).