In silico replication of association signals has been further facilitated by initiatives making genetic association study results and/or raw data publicly available (or available through application to an access committee), for example the Wellcome Trust Case Control Consortium (www.wtccc.org.uk), dbGAP (http://www.ncbi.nlm.nih.gov/sites/entrez?db=gap) and the European Genotype Archive (EGA, http://www.ebi.ac.uk/ega). Several emerging considerations, for example with respect to the anonymity of data, [63] avenues for communication between primary investigators and secondary users to facilitate a better understanding of the datasets and their appropriate uses, and suitable accreditation of involved parties, require resolution in order to optimize the use of publicly available raw data.
