For the past 2 years, GeneMANIA has automatically computed Gene Ontology enrichment on the set of genes displayed in the results page (i.e., the query list plus the related genes). The results of this analysis are available through the ‘functions’ tab that also allows coloring of the gene nodes by their annotated function (Figure 1). We also recently introduced the ‘function grid’, which is available in the gene ‘pop-up’ box that appears when you click on a gene. The function grid shows enriched functions for a given gene as a compact grid. Hovering the mouse over a square in the grid shows the enriched term. Highlighting a function term with a color in the Functions tab also colors the corresponding grid square. Opening multiple gene pop-ups simultaneously enables quick comparison of the grids to identify similar functional enrichment patterns among genes.
