sequences may impact biological processes by affecting the posttranscriptional regulation of the target genes. For example, a SNP (rs5186) located in the binding site of miR-155 can change the expression of a target gene (AGTR1), which is associated with blood pressure (32). The updated PolymiRTS database establishes links between polymorphisms in miRNA target sites and their possible functional impact in biological processes by including gene pathways for human and mouse from the KEGG database (33). We highlighted the genes with polymorphic miRNA target sites in the context of pathways (Figure 1). A browse page lists the KEGG pathways with at least one gene that has an SNP or INDEL in a miRNA target site. Clicking on the Pathway ID shows a list of all genes in the pathway with polymorphic miRNA target sites. Table 1.Summary of the updated contents of PolymiRTS databaseType of dataNumber of recordsHumanMouseSNPINDELSNPINDELPolymorphisms in miRNA target sitesIdentified by CLASH experiments22 9791047NANAWith other experimental supportsa190017080173Predicted from TargetScan358 87442 099353 41261 691Polymorphisms in miRNA seeds2712314436Genes with polymorphic miRNA target sites in different classes of biological pathwaysHuman diseases15157601752162Cellular processes1550822146997Environmental information processing17791014171496Genetic information processing1050425100445Metabolism18728452313150Organismal Systems18479692058199Genes associated with human traits in GWAS4830NAaPAR-CLIP, HITS-CLIP, microarray, pSILAC, reporter assay, western blot, etc.
