by a shared single variant. Because the PPP6C-centered association locus extends into the nearby genes SCAI and RABEPK, and significant predicted genetically driven differential expression of SCAI was also observed, we cannot exclude the possibility that these other genes play a role in, or are responsible for, the PPP6C-OA association. However, the degree of gene expression/variant association colocalization for PPP6C across brain tissues suggest it as the leading candidate for follow-up studies.
