The difficulty in working with bioactive lipids given their hydrophobicity, structural variability, and short half-lives has been a significant impediment to the investigation of their functional roles in biology. Thus discoveries indicating their major roles in signal transduction was delayed until recently [1]. Historically nucleic acids were viewed as being the blueprint of the cell and proteins as the machinery that ran it. Early views of lipids being merely structural components or fuels clearly reduced enthusiasm towards studying their functions. However, there is a growing body of literature that addresses the activity of the polyunsaturated fatty acids (PUFAs) and the resulting oxylipins in modulating signal transduction and neurotransmission [2–5]. This has been a shift in understanding because bioactive lipids such as endocannabinoids and epoxy fatty acids (EFAs) do not fit the classical definition of neurotransmitters as they are not stored in vesicles or released from them. However they can freely diffuse through cell membranes. In contrast to neurotransmitters, bioactive metabolites of fatty acids are often synthesized de novo or released from membrane bilayers upon cell stimulation [6]. Additionally unlike neurotransmitters
