Chunk #80 — 5. Procedures for evaluating pharmacological treatments targeting alcohol abuse and dependence — 5.9. Summary

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Animal models for medications development targeting alcohol abuse using selectively bred rat lines: neurobiological and pharmacological validity.

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findings provide support for (a) heterogeneity in the efficacy of pharmacological manipulations on alcohol self-administration by different alcohol-preferring rat lines, (b) the hypothesis that these rats lines may represent models of different subtypes of alcoholics, and (c) the need for testing promising compounds in more than one line of alcohol-preferring rats and with more than one ethanol self-administration procedure.