There are several important applications of the neurofeedback protocols for enhancement of cognitive performance in healthy subjects (reviewed in Vernon 2005). This promising new line of neurofeedback-based cognitive neuroscience research (Barnea et al. 2005; Egner and Gruzelier 2001, 2003, 2004a, b; Egner et al. 2004; Vernon et al. 2003) has significant potential to elucidate neurobiological mechanisms explaining how neurofeedback training may alter and enhance cognition and behavioral performance in patients with SUD as well.