Chunk #31 — HOW DO NEURAL SIGNATURES ASSOCIATED WITH AUD HELP ELUCIDATE THE ROLE OF BRAIN FUNCTION IN THE RISK AND CONSEQUENCES OF ALCOHOL USE AND AUD ACROSS THE LIFESPAN? — How do genomic factors influence brain functioning across the lifespan and contribute to antecedents and resilience for AUD? — Genome‐wide association studies (GWAS) of neurophysiological phenotypes
GIRK2 activation accounts for some of the variations in frontal theta oscillations seen in COGA families. We used COGA's longitudinal data to examine the neurodevelopmental trajectories of these frontal theta ERO phenotypes in the same visual oddball task during adolescence and young adulthood 44 , 52 and found age‐ and sex‐specific effects of the KCNJ6 variants 52 between the aged of 12–25. In another example of this approach, in the same adolescent and young adult sample in a reward processing task, frontal theta power EROs increased as a function of the minor allele dose of KCNJ6 SNP rs702859 during the loss condition 65 (Figure S1) These findings have implications for understanding the mechanisms through which genetics can influence neuronal circuits and indirectly, reward related behaviors. Ongoing research aims to determine functional significance of these GIRK2 variants in iPSC studies in COGA families 125 (see 5. Functional Genomics).
