In summary, RVTESTS is an efficient and comprehensive tool for sequence-based association analyses. As the cost of sequencing continues to decrease (e.g. a milestone of whole-genome sequencing for $1000 has been recently attained), population-based genetic studies will soon reach another scale. The speed and scalability advantage of RVTESTS will be even more critical when applied to these ultra-large scale datasets. We envision that our program will continue to make valuable contributions to the study of rare genetic variants in complex human diseases.
