Chunk #10 — Endocannabinoid Variants and Childhood Adversity Predict Cannabis Dependence Symptoms and Amygdala Habituation — The Endocannabinoid System and Cannabis Involvement
this strong preclinical evidence, much of the extant literature on specific genes and polymorphisms within the eCB system influencing cannabis phenotypes (e.g., Filbey, Schacht, Myers, Chavez, & Hutchison, 2010; Haughey, Marshall, Schacht, Louis, & Hutchison, 2008; Schacht, Selling, & Hutchison, 2009) remains unreplicated or has yielded null results (Agrawal & Lynskey, 2009). Furthermore, variation in eCB genes along the anabolic and catabolic pathways has been largely neglected.
