example of progressive MS (38), RGMa was found in active and chronic lesions, and in normal-appearing gray and white matter, and was expressed by cellular meningeal infiltrates in autopsy material. Levels of soluble RGMa in the cerebrospinal fluid were decreased in progressive MS patients for whom treatment resulted in functional improvement. Antibody-mediated neutralization of RGMa or downregulation of RGMa can result in neuroprotection and enhanced functional recovery (38). Whether RGMa plays similar roles in OD patients and thereby modulates addiction risk warrants further study.
