In the replication phase of our GWAS of general risk tolerance (combined n = 35,445), we meta-analyzed summary statistics from ten smaller cohorts. Additional details on cohort-level phenotype measures are provided in Supplementary Table 4. The cohorts’ survey questions differ in terms of their exact wording and number of response categories, but all questions ask subjects about their overall or general attitudes toward risk. The genetic correlation9 between the discovery and replication GWAS is 0.83 (SE = 0.13). 123 of the 124 lead SNPs were available or well proxied by an available SNP in the replication GWAS results. Out of these 123 SNPs, 94 have a concordant sign (P = 1.7×10–9) and 23 are significant at the 5% level in one-tailed t tests (P = 4.5×10–8) (Supplementary Fig. 3). This empirical replication record closely matches theoretical projections that take into account sampling variation and the winner’s curse (Supplementary Note).
