Overall the Think Tank stressed the importance of careful consideration of design and analysis in studies of GxE for characterization and for discovery. The design and analysis should be motivated by the underlying scientific question and rationale, and key items—including replication, power, measurement error and credibility— should be considered. As the field moves forward we will need to consider additional designs and analytical approaches in order to move from the current small number of success stories to a better understanding of the interplay of genetic and environmental factors.
