Chunk #24 — Materials and Method — Analytic Plan — Polygenic score creation

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Incorporating Functional Genomic Information to Enhance Polygenic Signal and Identify Variants Involved in Gene-by-Environment Interaction for Young Adult Alcohol Problems.

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locations with those of the 1000 Genomes-imputed FinnTwin12 dataset. There were 1,831,837 SNPs in common after filtering, pruned for LD to 193,884 SNPs (31,358 and 15,239 below p thresholds of .05 and .01, respectively). Of these, 76,913 (39.7%) SNPs were located in a DHS, of which 13,593 (43.3% of GW) and 6,918 (45.4% of GW) met p value thresholds of .05 and .01. Height (in centimeters) was measured in the FinnTwin12 sample by a self-report survey item at age 22.