The tests were two-tailed. In order to know whether there are other polymorphisms in strong linkage disequilibrium (LD) with this SNP in Asians and Europeans, haplotype construction, counting, and LD block defining over a broader genomic region of ADH1C were performed separately using the genotypes of 30 European and 90 Asian samples from HapMap (release 23a and ncbi_b36). The analysis procedure and additional LD information on the gene cluster (ADH7, ADH1C, ADH1B and ADH1A) and other statistical approaches (e.g., fail-safe analysis) were described previously(Li et al. 2011).
