As in adulthood, heavy alcohol use during adolescence has been linked to abnormalities in white and grey matter tissue volume [26,27,58,59,65], brain function [4,83,91,93], and neuropsychological performance [17,80,92,110]. Adolescent drinking is particularly important given its potential to interfere with maturational processes such as myelination and synaptic organization that continue throughout adolescence and into early adulthood [13,33-35,71].
