disequilibrium. Thus, linkage disequilibrium tends to increase the further away a population is from Africa (Conrad et al., 2006), consistent with the hypothesis that humans migrated out of Africa, experiencing severe population bottlenecks on the way to colonizing the rest of the world (DeGiorgio et al., 2009, Jakobsson et al., 2008). Standard GWAS approaches do not work so well in African populations (Teo et al., 2010).
