propose a new strategy to calculate PRS using variants that had the same directions of effects in discovery GWAS. Since study-specific variants and variants having small P-values due to random variations were excluded, we hypothesized that the performance of PRS would be improved. We tested for significant differences in PRS between AUD cases and alcohol-using controls, and in individuals with different numbers of lifetime DSM-5 AUD criteria endorsed (as a measure of AUD severity) in target dataset as well as subsamples with positive, unknown, and negative family history of AUD. We then tested whether PRS were associated with AUD diagnosis and AUD severity, and compared the performance of PRS with measures of family history of AUD.
