of hundreds of cases rather than tens, leading to more stable estimates in the regression analysis. Platform-specific QQ-plots (S5A–S5C Fig) showed no indication of systematic bias (genomic inflation factor λ = 1.00–1.01). The results from the meta-analysis are shown in Figs 6 and 7 (genomic inflation factor λ = 1.00). We observed a strong association located downstream of the F5 gene (strongest associated SNP: rs2040445, OR = 2.17, 95% CI: 1.79–2.63, p = 2.70x10-15). We also observed genome-wide significant associations for the ABO locus (strongest associated SNP: rs2519093, OR = 1.36, 95% CI: 1.23–1.49, p = 1.51x10-10) and a nominal association (P = 0.007) with the previously VTE-associated F11 locus. For both the F5 and ABO regions (S6A and S6B Fig, S2 Table), our top SNPs showed moderate correlation with previously reported top SNP (ABO locus: r-sq = 0.53 for rs529565 and rs2519093 and F5 locus: D’ = 1.00, r-sq = 0.00 for rs6025 and rs2040445 and D’ = 1.00, r-sq = 0.03 for rs4524 and rs2040445). Using a significance level of p = 0.05, three of nine known VTE SNPs [54], showed association with VTE in our data, however, the directions of association were the same as previously observed
