Chunk #27 — Materials and Methods — Genotyping of SNPs

Source

Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966.

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The 48 SNPs from the recent GWA scans [4]–[6] or their proxies represent 43 separate loci (TRIP11, GPR126, LCORL with two SNPs and CDK6 with three SNPs in or near each). The SNPs in or near TRIP11, GPR126 and CDK6 were in high LD with each other in the NFBC1966 sample (r2 = 0.32–0.97) and therefore were counted as one signal per gene, giving the total number of 44 independent (r2≤0.12) signals within 43 loci.