to mediate the volume of alcohol an individual can consume comfortably. Because this phenotype is most common in East Asian populations, occurring in nearly 40% of individuals in the present study but less than 10% of Europeans (Whitfield and Martin 1996), its potential influence is enhanced by this sample selection, while unlikely to play a major role in populations of European or African biogeographic ancestry. “Maximum drinks” is a continuous measure that is highly correlated with AD (Dick et al. 2006; Grant et al. 2009; Kendler et al. 2010; Dick et al. 2011). Its inclusion increases power by giving meaningful values for individuals without AD and a useful range among those with the disorder.
