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Chunk #5 — Results — Enrichment in Expression QTLs in Neural Tissues

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Dissection of a QTL hotspot on mouse distal chromosome 1 that modulates neurobehavioral phenotypes and gene expression.
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In this section, we summarize the number of expression phenotypes that map to Qrr1 in different tissues and mouse crosses. The results are based on the analysis of 18 array datasets that provide estimates of global mRNA abundance in neural and non-neural tissues from six different crosses. These crosses are—(i) BXD RI and advanced intercross RI strains derived from B6 and D2, (ii) CXB RI strains derived from B6y×BALB, (iii) LXS RI strains derived from ILS and ISS, (iv) B6×C3H F2 intercrosses, and (v & vi) two separate B6×D2 F2 intercrosses. These datasets were generated by collaborative efforts over the last few years [46], [47], [49]–[52] and some were generated more recently (e.g., the Illumina datasets for BXD striatum and LXS hippocampus, and BXD Hippocampus UMUTAffy Exon Array dataset). All datasets can be accessed from GeneNetwork (www.genenetwork.org).