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Chunk #15 — Results — Association With FTND

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Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence.
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We conducted haplotype analyses for markers rs16969968, rs1051730, and rs2869546 since these markers showed significant or marginal associations in both VAANX-ND and VAFTND samples. In these analyses, we found that the major haplotypes were the same in the two samples, and that their frequencies were similar. In association analyses, haplotype A-A-T or 2-2-1 was significantly associated FTND scores in both samples (Table IV). These results were consistent with that observed in the single marker analyses.