The neuroanatomical loci of the SR mediated reduction in ethanol self-administration are likely to involve many of the brain regions typically associated with addiction, but at present there is a paucity of datasets with this level of resolution. Hansson et al (2007) report that microinjection of SR into medial PFC reduces ethanol self-administration, but injections into the dorsal striatum did not affect the number responses for ethanol. In a complementary study, microinjection of SR in the NAc was found to reduce ethanol self-administration (Caillé et al., 2007). Future studies will need to replicate these findings as well as examine the role of other brain regions like the VTA and amygdala in mediating the effects of SR on ethanol consumption.
