Highly recurrent CNVs were assigned to one or more disorder based on the following approach (Figure S1B, available online). CNVs were assigned to the phenotype for which they met rigorous case-control criteria based on criteria described above. This was “strict” criteria for association. Further, significant CNVs were assigned to additional disorder categories based on “broad” criteria if a study participant with a primary disorder is reported to have symptoms meeting criteria for another disorder. An example of broad criteria is if a child with a recurrent CNV from an ASD study is described as having co-occurring ID, then the given CNV was coded for both ASD and ID disorders.
