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Chunk #27 — Discussion — Relationship to activity in the theta band

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Current source density measures of electroencephalographic alpha predict antidepressant treatment response.
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As previously observed (29), the spectral loadings of the low-alpha/theta factor extend below the conventional 8 Hz border into theta. Consequently, conventional qEEG measures based on standard frequency band cutoffs would unjustifiably split the factor in two, just below its peak (Fig. 1A; see also Figures S4 and S5 in the Supplement). For this reason, some differences reported here between treatment responders and nonresponders might have previously been attributed to theta activity.