It is interesting in this context to compare the overexpression models to APP knock-in mice harboring the Swedish mutation introduced into the mouse APP gene.48 These mice should represent the most authentic model of human FAD in the mouse, and because the 3 amino acid differences between mouse and human APPs in the Aβ region were modified, these mice also produce human Aβ. Yet, despite increased Aβ production, no amyloid plaques or neuropathology develops in these mice.
