We tested for significant enrichment of eQTLs in various functional and regulatory features defined using experimentally derived annotations from the ENCODE [8] and Epigenomics Roadmap [9] projects and provided with the GARFIELD software. Enrichment testing was performed for fetal brain transcript eQTLs with P values equivalent to FDR < 0.05. We tested the default of all features in all assayed cells/tissues (1004 tests), defining P values below the Bonferroni-corrected threshold of P < 4.98 × 10− 5 as significant.
