The largest (N = 293,723) GWAS of EA to date identified 74 approximately independent SNPs at genome-wide significance (hereafter, lead SNPs) and reported that a 10-million-SNP linear predictor (hereafter, polygenic score) had an out-of-sample predictive power of 3.2%10. Here, we expand the sample size to over a million individuals (N = 1,131,881). We identify 1,271 lead SNPs. In a subsample (N = 694,894), we also conduct genome-wide association analyses of variants on the X chromosome, identifying ten lead SNPs.
